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2ml
Bouliga
non cross-linked
12-30mg/ml
Bouliga Hyaluronic Acid Gel is a sterile, biodegradable, viscoelastic and non-pyrogenic solution of purified high molecular weight (2.1-2.4 million daltons) sodium hyaluronate in phosphate buffered saline solution. Highly purified sodium hyaluronate is obtained by bacterial fermentation. Sodium hyaluronate (sodium salt of hyaluronic acid), a natural polymer of the glycosaminoglycan family, is a mucopolysaccharide composed of disaccharide units of glucuronate consisting of repeating N-acetylglucosamine and glucuronate linked by β → 1,3 and β → 1,4 glycosidic acid. Sodium hyaluronate is present in phosphate buffered saline solution at concentrations of 10 mg/ml, 16 mg/ml, 20 mg/ml and 25 mg/ml. Sterile Sodium Hyaluronate Gel has a pH range of 6.8-7.8 and an osmolality of 270 to 400 mosm/kg, similar to synovial fluid The gel is available in prefilled 2 ml, 3 ml, 4ml and 5ml syringes. Each pre-filled syringe is in a sterile single pack.
Intended Use:
Bouliga is used to reduce pain associated with osteoarthritis in joints by supporting synovial fluid through intra-articular injection and allowing synovial fluid to regain its viscoelastic properties. It improves joint mobility by reducing or eliminating pain.
Instructions for Use:
Strict aseptic administration technique must be followed when performing intra-articular injection. Remove the joint effusion before injecting Bouliga; the same needle must be used for effusion removal and Bouliga injection. Carefully remove the protective cap of the syringe. Screw the 18 G and 22 G diameter needle tightly through the luer lock. Secure the needle tightly while holding the luer hub firmly to ensure a tight seal and prevent leakage during administration. Do not overtighten or apply excessive force when inserting the needle or removing the needle guard, otherwise the syringe tip may break. Before injection, the site must be disinfected with appropriate disinfectant. Then, the Bouliga gel is injected into the joint.
Dosage and Administration:
Bouliga should only be administered by a doctor for intra-articular injection therapy. Remove the cap of the pre-filled syringe, the luer lock and screw a suitable sharp-tipped sterile needle onto the luer lock. Use a needle of appropriate diameter and length depending on the location of the joint to be treated. It is recommended to use a disposable needle. Remove air bubbles from the syringe before injection. Administration times vary depending on the concentration of the products. Depending on the joint size: 2 ml, 3 ml, 4ml and 5ml injections can be administered 1, 3 or 5 times. The beneficial effects of 1, 3 or 5 consecutive treatments last for at least 6 months. Multiple joints can be treated simultaneously and treatment cycles can be repeated. In case of effusion accompanied by severe pain: First of all, the patient is followed up, and in many patients the condition resolves spontaneously without any intervention, -If deemed necessary, the joint is punctured to drain the product, or the joint space is punctured with 2 needles, fluid is administered through one needle (saline) and fluid is withdrawn through the other needle to clean the joint space. When performing these procedures, strict aseptic application technique should be followed as stated in the "Instructions for Use" section.
Warnings and Precautions:
Don’t use for pregnant woman, patient who is allergic to any ingredients of this product, or who is using muscle flabbiness diseased medications, or who is allergic to Glenn’s positive bacterial proteins. Contraindication: The following situation should prohibit use: Hypersensitivity to any component of this product. Joint inflammation in acute infections Side effects: After treatment, there might be have some symptoms of swelling, flush, pain, subcutaneous blood stasis, or soft loose feeling on the injection area. These symptoms would be alleviated automatically within one week or so. Expiration date: 2 years NOTE: It is recommended to place an ice pack on the treated joint for 5-10 minutes to prevent pain and swelling.
Bouliga Hyaluronic Acid Gel is a sterile, biodegradable, viscoelastic and non-pyrogenic solution of purified high molecular weight (2.1-2.4 million daltons) sodium hyaluronate in phosphate buffered saline solution. Highly purified sodium hyaluronate is obtained by bacterial fermentation. Sodium hyaluronate (sodium salt of hyaluronic acid), a natural polymer of the glycosaminoglycan family, is a mucopolysaccharide composed of disaccharide units of glucuronate consisting of repeating N-acetylglucosamine and glucuronate linked by β → 1,3 and β → 1,4 glycosidic acid. Sodium hyaluronate is present in phosphate buffered saline solution at concentrations of 10 mg/ml, 16 mg/ml, 20 mg/ml and 25 mg/ml. Sterile Sodium Hyaluronate Gel has a pH range of 6.8-7.8 and an osmolality of 270 to 400 mosm/kg, similar to synovial fluid The gel is available in prefilled 2 ml, 3 ml, 4ml and 5ml syringes. Each pre-filled syringe is in a sterile single pack.
Intended Use:
Bouliga is used to reduce pain associated with osteoarthritis in joints by supporting synovial fluid through intra-articular injection and allowing synovial fluid to regain its viscoelastic properties. It improves joint mobility by reducing or eliminating pain.
Instructions for Use:
Strict aseptic administration technique must be followed when performing intra-articular injection. Remove the joint effusion before injecting Bouliga; the same needle must be used for effusion removal and Bouliga injection. Carefully remove the protective cap of the syringe. Screw the 18 G and 22 G diameter needle tightly through the luer lock. Secure the needle tightly while holding the luer hub firmly to ensure a tight seal and prevent leakage during administration. Do not overtighten or apply excessive force when inserting the needle or removing the needle guard, otherwise the syringe tip may break. Before injection, the site must be disinfected with appropriate disinfectant. Then, the Bouliga gel is injected into the joint.
Dosage and Administration:
Bouliga should only be administered by a doctor for intra-articular injection therapy. Remove the cap of the pre-filled syringe, the luer lock and screw a suitable sharp-tipped sterile needle onto the luer lock. Use a needle of appropriate diameter and length depending on the location of the joint to be treated. It is recommended to use a disposable needle. Remove air bubbles from the syringe before injection. Administration times vary depending on the concentration of the products. Depending on the joint size: 2 ml, 3 ml, 4ml and 5ml injections can be administered 1, 3 or 5 times. The beneficial effects of 1, 3 or 5 consecutive treatments last for at least 6 months. Multiple joints can be treated simultaneously and treatment cycles can be repeated. In case of effusion accompanied by severe pain: First of all, the patient is followed up, and in many patients the condition resolves spontaneously without any intervention, -If deemed necessary, the joint is punctured to drain the product, or the joint space is punctured with 2 needles, fluid is administered through one needle (saline) and fluid is withdrawn through the other needle to clean the joint space. When performing these procedures, strict aseptic application technique should be followed as stated in the "Instructions for Use" section.
Warnings and Precautions:
Don’t use for pregnant woman, patient who is allergic to any ingredients of this product, or who is using muscle flabbiness diseased medications, or who is allergic to Glenn’s positive bacterial proteins. Contraindication: The following situation should prohibit use: Hypersensitivity to any component of this product. Joint inflammation in acute infections Side effects: After treatment, there might be have some symptoms of swelling, flush, pain, subcutaneous blood stasis, or soft loose feeling on the injection area. These symptoms would be alleviated automatically within one week or so. Expiration date: 2 years NOTE: It is recommended to place an ice pack on the treated joint for 5-10 minutes to prevent pain and swelling.
